After I upgraded to macOS Sierra I had no luck with my Huawei USB stick. Reinstalled the crappy software and nothing.

Googled a bit and all I got was from El Capitan. Not bad actually, since the solution is basically the same.

How to get Huawei E3272 working on macOS Sierra

  1. Download Mobile Partner from Huawei support site (direct link Mobile Partner)
  2. Boot your Mac into Recovery mode, by holding down Command (⌘)-R immediately after turning on or restarting your Mac. Release when you see the Apple logo.
  3. Launch Terminal from the Utilities menu.
  4. Run:

    $ csrutil disable
    $ reboot

  5. Log into your account regularly and install the previously downloaded Mobile Partner.
  6. Plug your USB stick.
  7. Launch Mobile Partner and connect (you might need to setup a profile according to your ISP settings)
  8. Boot your Mac into Recovery mode, by holding down Command (⌘)-R immediately after turning on or restarting your Mac. Release when you see the Apple logo.
  9. Launch Terminal from the Utilities menu.
  10. Run:

    $ csrutil enable
    $ reboot

  11. Be happy!